White matter integrity of the whole brain is disrupted in ¢rst-episode schizophrenia
نویسندگان
چکیده
Di¡usion tensor imaging studies in schizophrenia have demonstratedlowerdi¡usion anisotropy withinwhitematter thatprovides information about brain white matter integrity.We have examined whether whitematter is abnormal in ¢rst-episode schizophrenia by using di¡usion tensor imaging. Twenty-one schizophrenic patients and healthy controls underwent di¡usion tensor imaging scans that analyzed by using a rigorous voxel-based approach.We found that fractional anisotropy inwhitematter of thepatientswas lower than that in controls at the cerebral peduncle, frontal regions, inferior temporal gyrus, medial parietal lobes, hippocampal gyrus, insula, right anterior cingulum bundle and right corona radiata. These results suggested that white matter integrity of the whole brain was disrupted in early illness onset of schizophrenia. NeuroReport 17:23^26 c 2006 LippincottWilliams &Wilkins.
منابع مشابه
White matter integrity of the whole brain is disrupted in first-episode schizophrenia.
Diffusion tensor imaging studies in schizophrenia have demonstrated lower diffusion anisotropy within white matter that provides information about brain white matter integrity. We have examined whether white matter is abnormal in first-episode schizophrenia by using diffusion tensor imaging. Twenty-one schizophrenic patients and healthy controls underwent diffusion tensor imaging scans that ana...
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